• br Introduction Hypertensive retinopathy is a disease

  2020-07-31

  

  Introduction Hypertensive retinopathy is a disease of the retinal microvasculature associated with elevated blood pressure (Fraser-Bell et al., 2017). Narrowing of retinal arterioles occurs in the early stage of the disease, and with persistent hypertension further vascular pathology develops in

• Introduction Determining how genes function together as biol

  2020-07-31

  

  Introduction Determining how genes function together as biological systems is a defining challenge of the genomic era. While genome sequences reveal the DNA blueprint of organisms, deciphering how this blueprint leads to biological function is challenging due in large part to the complexity of prot

• Expression of MGMT in human cells can be switched

  2020-07-31

  

  Expression of MGMT in human acridine orange can be switched off by enzymatic methylation of a cytosine residue in the MGMT promoter sequence. In this regard, both MGMT and the mismatch repair function MLH1 belong to a subset of DNA repair genes that are subjected to epigenetic control. In consequenc

• br Structure The presence of glycans

  2020-07-31

  

  Structure The presence of glycans on collagens has been first described in 1935, when Grassmann and Schleich assigned up to 1% of the mass of collagen to BAY 87-2243 [4]. Twenty years later, these carbohydrates were determined to be bound to the polypeptide chains through O-glycosidic linkages [

• Medaka Oryzias latipes is used as a

  2020-07-30

  

  Medaka (Oryzias latipes) is used as a useful model in radiation biology [10], [11]. RIC1 strain was isolated as a radiation-sensitive mutant strain of Medaka via N-ethyl-N-nitrosourea ENU-mutagenesis screening [12]. Previously, we established four RIC1 cell lines from each single embryo and reported

• Multivariate models take interactions between cytokines into

  2020-07-30

  

  Multivariate models take interactions between cytokines into account and were used to accurately distinguish samples from different time points in pregnancy. The distinction accuracy did not increase with increasing time between the gestational time points, indicating that the cytokine development d

• br Acknowledgement This research was

  2020-07-30

  

  Acknowledgement This research was supported by a grant from the National Research Foundation of Korea (NRF-2013R1A1A2011238) funded to Young-Mi Lee. Introduction Stroke is considered a serious disease with high morbidity and high mortality. More than 6 million deaths are reported each year wo

• flap inhibitor In general there are mainly three well known

  2020-07-30

  

  In general, there are mainly three well-known hypotheses to explain the biological mechanism underlying DRE: the transporter hypotheses, the chemical structure modification of the drug hypothesis and alteration of drug targets hypotheses. Multidrug transporters are supposed to result in AEDs resista

• br CXCR Among the CXCRs CXCR is the

  2020-07-30

  

  CXCR4 Among the CXCRs, CXCR4 is the most well studied receptor owing to its critical roles in development. CXCR4 has been discovered as a single copy gene in agnathan and gnathostome vertebrates except for teleosts where duplicated CXCR4 (CXCR4a and 4b), and their ligands CXCL12 (CXCL12a and 12b)

• To further functional study we found that the

  2020-07-30

  

  To further functional study, we found that the mRNA levels of fatty 5 03 β-oxidation–related genes such as ACSL1, CPT1, CACT, and HADHB were increased after PA treatment and regulated by PKCζ (Figure 5). The SIRT6 RNAi and T294A mutant SIRT6 transfected study also showed that phosphorylation SIRT6

• br Results and discussion First the

  2020-07-30

  

  Results and discussion First, the results for n-pentane diluted and propane diluted bitumen with CPA-C5 and CPA-C3 characterization approaches are discussed and compared. Then, the extension of the model to other bitumens and solvents is examined. Finally, the limiting number of pseudo-components

• First KEGG and GO annotation were conducted for these genes

  2020-07-29

  

  First, KEGG and GO annotation were conducted for these 1251 genes. Then, combining the pathway enrichment analysis, we explored how these genes could function in breast cancer. We discovered that neuroactive ligand-receptor interaction was the most enriched pathway, which comprised numerous G protei

• Streptozocin To directly test the hypothesis that

  2020-07-29

  

  To directly test the hypothesis that hepatic steatosis leads to insulin resistance, we studied transgenic mice that overexpress human DGAT enzymes, which catalyze the final step of triacylglycerol (TG) biosynthesis (Buhman et al., 2001), in the liver. We focused on mice overexpressing DGAT2 (Liv-DGA

• Cytokine evaluation in MPN dates back to Early studies

  2020-07-29

  

  Cytokine evaluation in MPN dates back to 1997. Early studies have evaluated limited subtypes of cytokines because of technology limitations or kit restrictions. Now with the application of multiplex cytokine assays, a panel of cytokines can be measured per sample at the same time and can provide mor

• These changes in the corticolimbic system may be

  2020-07-29

  

  These changes in the corticolimbic system may be mediated by the action of neuropeptide corticotropin-releasing factor (CRF), which interacts with two G-protein-coupled corticotropin-releasing factor CRF receptors, type 1 (corticotropin-releasing factor CRF1 receptor) and type 2 (corticotropin-relea

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