• To shed more light on the binding of

  2021-09-23

  

  To shed more light on the binding of benzophenanthridine to GlyT1, we studied how the replacement of certain residues around the sanguinarine sensitive cysteine 475 previously identified (Jursky et al., 2012) affects GlyT1 inhibition of by these alkaloids. Based on these results we propose a putativ

• Xenobiotic metabolizing enzymes are classified

  2021-09-23

  

  Xenobiotic metabolizing enzymes are classified as being phase I, phase II and transporter enzymes, with phase I enzymes metabolizing lipophyllic xenobiotics to make them more polar so that the phase II enzymes can perform the necessary conjugation reactions that afford elimination. Although the phas

• Levodopa Interruption of glucagon signaling pathway

  2021-09-23

  

  Interruption of glucagon signaling pathway targeting glucagon receptor (GCGR) by gene knockout, antisense oligonucleotides or specific antagonists induces α-cell hyperplasia and alleviates hyperglycemia and other metabolic symptoms in diabetic animals and patients [[7], [8], [9]]. Here we used a ful

• Whether or not SMO and SMO dependent HH signaling play

  2021-09-23

  

  Whether or not SMO and SMO-dependent HH signaling play a role in hematopoiesis is a subject of strong controversy. Obviously, the effects of SMO deletion are highly contextual and dependent on the timing of deletion. transplanted murine Smo−/− fetal liver TW-37 into sublethally irradiated mice and o

• The most classic case of acquired and

  2021-09-23

  

  The most classic case of acquired and relapsing epilepsy is temporal lobe epilepsy (TLE), which originates from the hippocampal formation, a structure situated in the mesial temporal lobe (Majores et al., 2007). Our experiment used the prominent pilocarpine-induced TLE model. Systemic administration

• br Mammalian chromosomal DNA binds to various proteins and t

  2021-09-22

  

  Mammalian chromosomal DNA binds to various proteins and the DNA-protein complexes form DNA packaging units, called nucleosomes. Histones are the chief protein components of nucleosomes and perform pivotal functions in chromosomal gene regulation. Moreover, many types of chemical modifications of h

• In our previous study we designed and synthesized

  2021-09-22

  

  In our previous study, we designed and synthesized compounds of A series from the starting material 4-hydroxy-3-methoxycinnamic azilsartan medoxomil receptor (ferulic acid). These compounds with R group being amino acid residues, fatty acyl group and sulfuryl group showed moderate HDAC inhibition an

• In our previous studies examining erectile responses in

  2021-09-22

  

  In our previous studies examining erectile responses in sGCα1−/− mice, we found that the sGCα1 subunit was required to obtain proper erectile responses to substances generally known to exert their actions by sGC.17, 18 Based on our previous observation of residual relaxing responsiveness to exogenou

• The results obtained through in vitro in vivo

  2021-09-22

  

  The results obtained through in vitro, in vivo and in silico corroborated with those presented by other works and indicate that CpMutY is involved in oxidative damage repair in this organism. In this regard, MutY conservation in evolutionarily distant bacteria suggests that this protein plays an imp

• Here we reported series of

  2021-09-22

  

  Here, we reported series of carbohydrate-modified compounds containing a dibromo substituted benzene ring which was derived from the red alga (). The conformation flexibility of isrib and their polyol structures give them many unique biological properties as we have described earlier. More interes

• Accordingly it is tempting to

  2021-09-22

  

  Accordingly, it is tempting to speculate that the maintenance of a stimulus representation in the A2 state for a short period of time after the presentation of a specific stimulus (i.e. self-generated priming) may rely upon GluR-A-dependent synaptic plasticity. If this were the case, GluR-A 84 9 rec

• A number of anti diabetic drugs are

  2021-09-22

  

  A number of anti-diabetic drugs are available that inhibit α-glucosidase activity, including acarbose, voglibose and miglitol [6,7]. These inhibitors, however, also exhibit undesirable side effects, such as adverse gastrointestinal symptoms and liver toxicity [8,9]. For diabetics, it would therefore

• SB 203580 hydrochloride The effects of galanin on anxiety

  2021-09-18

  

  The effects of galanin on anxiety may depend on the site of drug administration, on the galanin receptor subtypes activated and on the animal models of anxiety employed (Barrera et al., 2005, Holmes and Picciotto, 2006, Soares et al., 2016a, Soares et al., 2016b). For instance, administration of gal

• br Medium to long chain fatty acids Medium

  2021-09-18

  

  Medium- to long-chain fatty acids Medium- to long-chain fatty acids impart a wide range of physiological effects. Medium-chain and long-chain fatty acids have 6–12 carbons and >12 carbons, respectively. As the energy source, these fatty acids are supplied primarily by food intake, biosynthesis, a

• On the contrary the benzhydrol

  2021-09-18

  

  On the contrary, the benzhydrol series showed modest activity with EC of two digit micromole. The bulkiness of the OSI-420 receptor tail may be the reason for the low activity. Interestingly, introduction of H-bonding groups, such as OMe in and CF in , slightly improved the activity compared to th

16039 records 603/1070 page Previous Next First page 上5页 601602603604605 下5页 Last page