• The consensus amino acid recognition sequence for p

  2023-09-11

  

  The consensus amino Ellipticine receptor recognition sequence for p38α substrates is (Ser/Thr)Pro (Cuadrado and Nebreda, 2010), typically assisted by upstream docking motifs (Remenyi et al, 2005, Sharrocks et al, 2000). P450c17 has 32 Ser and 25 Thr residues, of which only Thr 341 and Ser 427 are im

• CHK has been reported to be the kinase responsible for

  2023-09-11

  

  CHK1 has been reported to be the kinase responsible for H3.3S31 phosphorylation in human ALT cancer 900 80 . However, in our study, knockdown of CHK1 in HEK293F (Figs. S1c and S6) or HeLa S3 (data not shown) cells did not result in a significant decrease in H3.3S31ph, which is in agreement with an e

• The approach of enzymatically converting an analyte and dete

  2023-09-11

  

  The approach of enzymatically converting an analyte and detecting it by the resulting small pH changes near the reduced graphene oxide (rGO) surface has successfully been pursued in case of urea (Piccinini et al., 2017). Furthermore, this work reported that electrostatic layer-by-layer (LbL) assembl

• br Experimental methods br Acknowledgments br Introduction L

  2023-09-09

  

  Experimental methods Acknowledgments Introduction Long-term potentiation (LTP) and long-term depression (LTD) at excitatory synapses are thought to underlie experience-dependent learning and memory. These synaptic plasticity mechanisms are best characterized at hippocampal CA1 synapses, whe

• br Understanding AD through Transcriptome Analysis Both clas

  2023-09-09

  

  Understanding AD through Transcriptome Analysis Both classical gene discovery and pathway-based analysis of AD GWAS shed light on the range of biological processes that contribute to AD in addition to amyloid pathology. The straightforward interpretation and functional investigation of the associ

• br The AHR functions in the

  2023-09-09

  

  The AHR functions in the immune system – a tsunami of exciting findings The research of recent years has convincingly established an important function of the AHR in linking chemical environmental cues to immune responses [21,22], and reviewed in [1,23]. As a side effect, a view of the AHR as “Th

• Considering the physicochemical stability results on Fig it

  2023-09-09

  

  Considering the physicochemical stability results on Fig. 5, it was observed that the particles are stable when they are stored at 4 °C for 30 days. After day 30, a significant increase was observed in particle size, but at the end of the 90 days the SLN particle size is still below 100 nm. Stabilit

• br Autophagy inducers Macroautophagy is often

  2023-09-09

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of Sephin 1 and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing sensitivity of ca

• The main function of ATR

  2023-09-09

  

  The main function of ATR/CHK1 signaling is activating potassium hydrochloride checkpoint arrest for S and G2 phases in mammalian cells. There are three checkpoints in response to DNA damage: G1/S, G2/M, and S-phase. The G2/M checkpoint can prevent cells that incur DNA damage in G2 phase or progress

• Analysis of ASK crystal structures as well as

  2023-09-09

  

  Analysis of ASK1 crystal structures as well as an investigation of how SB 747651A dihydrochloride 4 might bind were undertaken to understand opportunities for engaging Gln756. To this end a docking model derived from PDB 3VW622 was used to predict the binding mode of amide 4 in the ASK1 active site

• ASK has been identified as an ASK binding protein Wang

  2023-09-09

  

  ASK2 has been identified as an ASK1 binding protein (Wang et al., 1998). ASK1 supports the stability and active configuration of ASK2 in the heteromeric complex, while ASK2 has been found to activate ASK1 by direct phosphorylation (Takeda et al., 2007). Unlike ASK1, which is ubiquitously expressed i

• br STAR Methods br Acknowledgments We thank Simcere Pharmace

  2023-09-08

  

  STAR★Methods Acknowledgments We thank Simcere Pharmaceuticals, Nanjing, China, for providing a rabbit anti-VEGF neutralizing monoclonal antibody. We thank Dr. Schlisio in the Ludwig Institute for Cancer Research, Karolinska Institute, for assistance with hypoxia assay. Y.C.’s laboratory is sup

• Within the thrombus there is heterogeneity

  2023-09-08

  

  Within the thrombus, there is heterogeneity in the activation of EPZ-6438 based on the concentration gradients of soluble agonists emanating from the site of vascular injury, which has been excellently reviewed by Tomaiuolo et al.[1]. As part of the coagulation cascade, active thrombin is generated

• Nrf br AhR br Nrf and AhR

  2023-09-08

  

  Nrf2 AhR Nrf2 and AhR: friends or foes for energetic metabolism? Perspectives in carcinogenesis upon xenobiotic exposure Acknowledgements Introduction Integration of endogenous and exogenous signals via appropriate receptors is at the core of biological differentiation and adaptive r

• br Introduction Psychostimulant abuse and addiction remain a

  2023-09-08

  

  Introduction Psychostimulant abuse and addiction remain a societal problem in the United States. The latest statistics from the National Survey on Drug Use and Health indicate that slightly less than one million people over the age of 12 report having a cocaine use disorder (NSDUH, 2016). Additio

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