• The relationship between the apelinergic and opioid

  2024-04-28

  

  The relationship between the apelinergic and opioid systems has been previously reported (Lv et al., 2011, Yang et al., 2010). Lv and colleagues showed that naloxone has a suppressive effect on apelin-induced depression-like behavior in mice (Lv et al., 2012a). Furthermore, heterodimerization of GPC

• As the experimental procedure used could reflect agonist sti

  2024-04-28

  

  As the experimental procedure used could reflect agonist-stimulation of both anterograde and retrograde APJ trafficking, as has been described for the δ-opioid peptide receptor (Zhang et al., 2006b, Zhang et al., 2006a), receptor internalization was more directly monitored by loading cell surface HA

• Recently AFF was used to convert an FN

  2024-04-28

  

  Recently, AFF was used to convert an FN3-based binder specific to the Src homology 2 (SH2) domain of cAbl kinase into an allosterically regulated, intermolecular fluorescent switch (Figure 2D). Binding to cAbl kinase co-operatively stabilized the assembly of the FN3-based binder from two partial fra

• br Future directions outlook Peptide based macrocycles

  2024-04-28

  

  Future directions-outlook Peptide-based macrocycles are among the privileged scaffolds in antibiotic drug discovery. Many compounds were discovered by natural product screening and developed unchanged, or as semi-synthetic derivatizations. Since the golden age of antibiotic discovery (1940s-mid 1

• Nanoparticles are submicrometric systems smaller than nm whi

  2024-04-28

  

  Nanoparticles are submicrometric systems smaller than 1000 nm which high surface area and composite materials may allow their greater interaction with biological membranes and control of the drug release. These features are directly associated with the efficacy of treatment and the presence of adver

• In this report we introduce

  2024-04-28

  

  In this report, we introduce a new method for identifying aminopeptidases. Because single substrates can be insufficient for enzyme identification, we used an entire library of substrates to obtain more information about enzyme activity and to directly detect aminopeptidases. Moreover, substrates ca

• Tacalcitol synthesis Phytoremediation technology is defined

  2024-04-28

  

  Phytoremediation technology is defined as the use of plants to remove contaminants from soils or to render them harmless, and is regarded as a cost-effective, environmental-friendly method for reclaiming soils contaminated by toxic metals (Lasat, 2002, Mahar et al., 2016, Marrugo-Negrete et al., 201

• There are two ways to transport FFAs into cells

  2024-04-28

  

  There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty LY3039478 transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is responsible

• Streptomycetes are a group of filamentous

  2024-04-28

  

  Streptomycetes are a group of filamentous Gram-positive, soil-inhabiting bacteria which have captured enormous screening interest because of their ability to produce and secrete a variety of SBE 13 HCl receptor and extracellular proteins [7]. Among the diverse antibiotics produced by Streptomycetes

• br Acknowledgments br Introduction Hypospadias is a

  2024-04-28

  

  Acknowledgments Introduction Hypospadias is a common congenital malformation in males, in which the urethral orifice is found on the ventral side of the penis as a result of incomplete fusion of urethral folds. The mean prevalence in per 10,000 live births from 1910 to 2013 were: Europe 19.9,

• The altered frequency of CD T cells

  2024-04-28

  

  The altered frequency of CD4+ T Cyclophosphamide monohydrate in 5-LO−/− mice led us to hypothesize that these leukocytes could be exerting a primary control of the inflammatory response. In fact, the lack of 5-LO resulted in the accumulation of CD4+CD25+ cells expressing Treg markers. It is plausib

• The first natural product described

  2024-04-28

  

  The first natural product described as 5-LO inhibitor was the polyphenol nordihydroguaiaretic TW-37 synthesis from the Mexican dessert plant Larrea divaricata in 1981 (Bokoch and Reed, 1981), short after the initial identification of 5-LO in 1979 (Borgeat and Samuelsson, 1979). Long time before mPGE

• Two parallel branches of the DNA damage dependent

  2024-04-27

  

  Two parallel branches of the DNA damage-dependent S-phase checkpoint are thought to co-operate by inhibiting distinct steps of DNA replication. One branch includes the phosphorylation of structural maintenance of chromosomes 1 (SMC1), a cohesin that is activated by ATM or ATR after IR treatment or r

• ATM is generally regarded to be the principal mediator

  2024-04-27

  

  ATM is generally regarded to be the principal mediator of the G1 Ketanserin checkpoint, whereas the induction of the intra-S-phase and G2/M checkpoints are usually primarily related to ATR function. However, several studies have demonstrated that, depending on the cellular context and type of DNA da

• Then Autodock was employed for site directed docking on AD

  2024-04-27

  

  Then, Autodock4.2 was employed for site directed docking on AD with the ligands of the cluster(s) having high binding affinities in VS II experiment (Morris et al., 2009). Docking protocols were followed as per our earlier report with 200 GA (genetic algorithm) run (Kalani et al., 2015). Likewise, l

15976 records 163/1066 page Previous Next First page 上5页 161162163164165 下5页 Last page