• March marked annual World TB Day this

  2019-04-20

  

  March 24 marked annual World TB Day, this year\'s theme being “reach the 3 million” who acquire tuberculosis every year but who do not get diagnosed, treated, or cured. Why do so many patients with this life-threatening infectious disease go under the radar? One reason, as Madhukar Pai and colleague

• In order to treat metastatic bone disease effectively all st

  2019-04-20

  

  In order to treat metastatic bone disease effectively all steps involved in the metastatic cascade need to be taken into account as for example the interactions between primary and secondary sites, tumour cell–bone cell cross talk and osteomimicri [8]. Therefore, concomitant targeting of both the tu

• gingerol En efecto lecturas atentas de estos textos

  2019-04-20

  

  En efecto, lecturas atentas de estos textos sabrán localizar “lo político” de su empeño signado, más allá de referirse o hacer mención gingerol políticas específicas, encontradas al paso en los lugares que visitan y recorren, o de hablar sobre los personajes políticos que conocen; más allá, pues, de

• br The sources of cholesterol

  2019-04-20

  

  The sources of cholesterol secreted into bile Bile formation is an osmotic process and solutes are actively transported into the canaliculus by primary active lipid transporters: ABCG5/G8 for biliary cholesterol secretion, ABCB4 for biliary phospholipid secretion, and ABCB11 for biliary bile acid

• In the past three decades along with rapid economic

  2019-04-20

  

  In the past three decades, along with rapid economic growth in China, there has been a striking increase in alcohol consumption, greater than in most other parts of the world (). Although the cftr inhibitor drinking level in China used to be far lower than in many high-income and middle-income coun

• br Hematopoietic cell transplantation HCT

  2019-04-20

  

  Hematopoietic cell transplantation HCT is generally recommended for AML patients with intermediate or high risk cytogenetics, when the aim of treatment is curative. However, elderly patients are seldom offered a transplant mainly due to concerns regarding toxicity, despite the fact that the main

• br Discussion Case reports of successful

  2019-04-19

  

  Discussion Case reports of successful chemotherapy desensitizations have been described for platinum agents, taxanes, anthracyclines, rituximab [8], and cytarabine [9], but not specifically clofarabine. For older patients with relapsed AML that are not candidates to receive anthracycline therapy,

• We have received funding from the

  2019-04-19

  

  We have received funding from the Wellcome Trust to develop a global atlas of podoconiosis. We aim to advance new knowledge on the geographical distribution and spatial epidemiology of the disease. A first step in this work will be to establish the geographical absence of disease by applying an evid

• Introduction The hippocampus is a critical brain region for

  2019-04-19

  

  Introduction The hippocampus is a critical brain region for episodic memory formation in rodents and humans [1]. Hippocampal neurons, especially CA1 neurons, are highly vulnerable to ischemic injury [2], and failure of hippocampal function causes memory impairment and reduced cognitive ability [3,4

• azidothymidine br Conflict of interest br

  2019-04-19

  

  Conflict of interest Introduction Idiopathic left ventricular tachycardia (ILVT) with a right bundle-branch block (RBBB) configuration and superior or left axis is a distinct entity that arises in the left ventricle, mostly because of a reentry mechanism and is usually verapamil sensitive [1–6

• br Discussion We successfully prevented the initiation of

  2019-04-19

  

  Discussion We successfully prevented the initiation of AF without inhibiting the AF-triggering APB, and eliminated the AF-triggering APB located close to the sinus node without damage to sinus node function. Nifekalant is an IKr antagonist that prolongs the duration of myocardial p38 inhibitors

• In the American College of Chest Physicians provided a guide

  2019-04-19

  

  In 2013, the American College of Chest Physicians provided a guideline to the preoperative physiological assessment of patients being considered for surgical resection of lung cancer. It has been recommended that patients must be assessed by a multidisciplinary team before operation, regardless of a

• br Results Compared to the respective untreated

  2019-04-19

  

  Results Compared to the respective untreated groups, the VT duration was shorter in clonidine-treated ETB-deficient rats during phase I and in wild-type rats during phase II (Fig. 1A). Heart rate (HR) increased in both untreated groups, but this response was blunted after clonidine, mainly in ETB

• mek inhibitors The WHO Safer Primary Care report has

  2019-04-19

  

  The WHO Safer Primary Care report has grappled head-on with the challenges associated with many variations in the scope, nature, and provision of primary care in different countries; insufficient data from low-income and middle-income country settings to inform priorities for care; the need to devel

• br Identidade negra e quilombola O uso

  2019-04-18

  

  Identidade negra e quilombola O uso da expressão “remanescentes” para classificar os agrupamentos negros, enquanto unidades que guardam correspondência histórica com os quilombos, motivou reflexões sobre seu significado. Adotamos o entendimento de que ao contrário do sentido de sobra ao qual pode

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