• br Discussion Case reports of successful

  2019-04-19

  

  Discussion Case reports of successful chemotherapy desensitizations have been described for platinum agents, taxanes, anthracyclines, rituximab [8], and cytarabine [9], but not specifically clofarabine. For older patients with relapsed AML that are not candidates to receive anthracycline therapy,

• We have received funding from the

  2019-04-19

  

  We have received funding from the Wellcome Trust to develop a global atlas of podoconiosis. We aim to advance new knowledge on the geographical distribution and spatial epidemiology of the disease. A first step in this work will be to establish the geographical absence of disease by applying an evid

• Introduction The hippocampus is a critical brain region for

  2019-04-19

  

  Introduction The hippocampus is a critical brain region for episodic memory formation in rodents and humans [1]. Hippocampal neurons, especially CA1 neurons, are highly vulnerable to ischemic injury [2], and failure of hippocampal function causes memory impairment and reduced cognitive ability [3,4

• azidothymidine br Conflict of interest br

  2019-04-19

  

  Conflict of interest Introduction Idiopathic left ventricular tachycardia (ILVT) with a right bundle-branch block (RBBB) configuration and superior or left axis is a distinct entity that arises in the left ventricle, mostly because of a reentry mechanism and is usually verapamil sensitive [1–6

• br Discussion We successfully prevented the initiation of

  2019-04-19

  

  Discussion We successfully prevented the initiation of AF without inhibiting the AF-triggering APB, and eliminated the AF-triggering APB located close to the sinus node without damage to sinus node function. Nifekalant is an IKr antagonist that prolongs the duration of myocardial p38 inhibitors

• In the American College of Chest Physicians provided a guide

  2019-04-19

  

  In 2013, the American College of Chest Physicians provided a guideline to the preoperative physiological assessment of patients being considered for surgical resection of lung cancer. It has been recommended that patients must be assessed by a multidisciplinary team before operation, regardless of a

• br Results Compared to the respective untreated

  2019-04-19

  

  Results Compared to the respective untreated groups, the VT duration was shorter in clonidine-treated ETB-deficient rats during phase I and in wild-type rats during phase II (Fig. 1A). Heart rate (HR) increased in both untreated groups, but this response was blunted after clonidine, mainly in ETB

• mek inhibitors The WHO Safer Primary Care report has

  2019-04-19

  

  The WHO Safer Primary Care report has grappled head-on with the challenges associated with many variations in the scope, nature, and provision of primary care in different countries; insufficient data from low-income and middle-income country settings to inform priorities for care; the need to devel

• br Identidade negra e quilombola O uso

  2019-04-18

  

  Identidade negra e quilombola O uso da expressão “remanescentes” para classificar os agrupamentos negros, enquanto unidades que guardam correspondência histórica com os quilombos, motivou reflexões sobre seu significado. Adotamos o entendimento de que ao contrário do sentido de sobra ao qual pode

• br Results and discussion br Authorship contributions br

  2019-04-18

  

  Results and discussion Authorship contributions Conflict of interest Acknowledgments This work is supported by grants from the United States National Institutes of Health/National Cancer Institute: R01 CA098472 and R01 CA170334. We thank Dr. Dan Zhang and Andy Awwad for technical assista

• br A hallmark of the past decade

  2019-04-18

  

  A hallmark of the past decade has been the remarkable progress made in reducing maternal and child mortality, an achievement credited in some measure to the Millennium Development Goals. The reduction in child deaths from an estimated 12·7 million under-5 deaths in 1990 to fewer than 6 million dea

• The incidence of AF in Japan was

  2019-04-18

  

  The incidence of AF in Japan was also reported from an early cohort of the Hisayama Study [32] in the period between 1961 and 1984. Similar to the reports from Western countries, the incidence of AF increased with age in both men and women (Fig. 7) [32]. In a recent report of an observational cohort

• Introduction Several types of cancers including those origin

  2019-04-18

  

  Introduction Several types of cancers, including those originating in the breast, prostate, and lung, have a propensity to metastasize to the bones [1,2]. Bone metastases severely impair skeletal metabolism, and result in important clinical sequelae, such as excruciating chronic bone pain and the s

• RANK RANKL The RANK RANKL signaling pathway is a critical

  2019-04-18

  

  RANK/RANKL: The RANK/RANKL signaling pathway is a critical component of both normal and malignant bone remodeling. RANK is a transmembrane signaling receptor and a member of the tumor necrosis receptor (TNF) superfamily that is found on the surface of OCL precursors [43,44]. RANK ligand (RANKL) is e

• Introduction Despite advances in breast

  2019-04-18

  

  Introduction Despite advances in breast cancer treatment, bone remains the most common site of gap-26 Supplier [1,2] occurring in around 70% of patients with metastatic disease [3]. Bone metastases are incurable and associated with significant morbidity in terms of fractures, pain, and reduced qua

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